Deciphering physiological role of the mechanosensitive TRPV 4 channel in 1 the distal nephron
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چکیده
3 M. Mamenko, O. Zaika, N. Boukelmoune, R. G. O’Neil, and O. Pochynyuk 4 Department of Integrative Biology and Pharmacology; The University of Texas Health Science Center 5 at Houston, USA 6 7 8 Please correspond with Oleh Pochynyuk at: 9 University of Texas Health Science Center at Houston, 10 Department of Integrative Biology and Pharmacology 11 6431 Fannin, Houston TX, 77030; 12 Ph. (713) 500-7466; Fx. (713) 500-7455; 13 [email protected]. 14 15 Running title: TRPV4 function in the DN 16 17 18 19 Articles in PresS. Am J Physiol Renal Physiol (December 10, 2014). doi:10.1152/ajprenal.00485.2014
منابع مشابه
Deciphering physiological role of the mechanosensitive TRPV4 channel in the distal nephron.
Long-standing experimental evidence suggests that epithelial cells in the renal tubule are able to sense osmotic and pressure gradients caused by alterations in ultrafiltrate flow by elevating intracellular Ca(2+) concentration. These responses are viewed as critical regulators of a variety of processes ranging from transport of water and solutes to cellular growth and differentiation. A loss i...
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تاریخ انتشار 2014